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Fc受體蛋白
FcR是免疫球蛋白Ig的受體，可通過與Ig的Fc段特定區(qū)域結合引起相應的細胞特異性免疫反應，起著連接機體體液免疫和細胞免疫的橋梁作用。FcR的基因多態(tài)性使其能引起多樣的細胞內生物效應，而這又與多種免疫相關疾病的發(fā)生發(fā)展密切相關，如自身免疫病SLE和RA。 Fc受體蛋白是免疫系統(tǒng)最為重要的蛋白家族之一，介導了抗體依賴的ADCP、ADCC及CDC效應，在免疫系統(tǒng)激活及抗體作用發(fā)揮中起到關鍵作用。
目前應用最廣泛的主要是IgG受體，包括FcRn和FcγR。FcγR可分為三類：FcγRI，F(xiàn)cγRII和FcγRIII。FcγRI與IgG具有高親和力(10-9M)，主要表達于單核巨噬細胞。FcγRII、FcγRIII與IgG具有低親和力(10-6M)，分布比較廣泛。FcγRII根據(jù)胞質區(qū)的結構不同，又分為FcγRIIa、FcγRIIb和FcγRIIc 3種類型，存在于B細胞、巨噬細胞、多形核細胞、血小板及單核細胞，且FcγRIIb是唯一抑制型受體。FcγRIII存在于粒細胞、NK細胞、巨噬細胞及活化的單核細胞。FcγR與抗體結合可以起到激活免疫細胞并產生內吞、吞噬、ADCC等作用。
人Fcγ受體結構圖（DOI: 10.1016/j.jaci.2020.06.036）
FcRn可以在酸性小泡內(pH < 7.0)和IgG結合，保護抗體大分子不被破壞；然后在pH等于7.4的血液環(huán)境下，釋放抗體大分子，如此可延長抗體的半衰期，這對抗體的藥效發(fā)揮有重要作用。
FcRn延長IgG半衰期的機制（DOI: 10.1038/nri2155）
愷佧生物基于對Fc受體蛋白的深入理解，并通過自己獨有的蛋白研發(fā)生產平臺SAMSTM成功研制出一系列高質量Fc受體重組蛋白產品，包括FcRn和FcγR的多種亞型及其突變形式，可實現(xiàn)抗體Fc區(qū)域的功能驗證，適合多種分析方法，助力抗體藥研發(fā)。
數(shù)據(jù)示例
Immobilized Human FcRn, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-FcRn Antibody, hFc Tag with the EC50 of 5.4 ng/ml determined by ELISA (QC Test).
Human FcRn, His Tag captured on CM5 Chip via anti-his antibody can bind Human IgG1 Fc, No Tag with an affinity constant of 0.28 μM as determined in SPR assay (QC Test).
Immobilized Human Fc gamma RIIIA (F176) , His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-Fc gamma RIIIA Antibody, hFc Tag with the EC50 of 10.1 ng/ml determined by ELISA (QC Test).
Human Fc gamma RIIIA (F176) , His Tag captured on CM5 Chip via anti-His antibody can bind Rituximab, hFc Tag with an affinity constant of 0.92 μM as determined in SPR assay (QC Test).
產品列表
| 貨號 | 蛋白名稱 | 種屬 | 標簽 | 表達體系 | |
|---|---|---|---|---|---|
| FRI-HM464 | Fc gamma RI / CD64 | Human | C-His-Avi | HEK293 | 立即詢價 |
| FRI-HM464B | Biotinylated Fc gamma RI / CD64 | Human | C-His-Avi | HEK293 | 立即詢價 |
| FRI-MM164 | Fc gamma RI / CD64 | Mouse | C-His | HEK293 | 立即詢價 |
| FRI-RM164 | Fc gamma RI / CD64 | Rat | C-His | HEK293 | 立即詢價 |
| CDA-HM432 | Fc gamma RIIA / CD32a (H167) | Human | C-His-Avi | HEK293 | 立即詢價 |
| CDA-HM432-UL | Fc gamma RIIA / CD32a (H167), Ultra Low Endotoxin | Human | C-His-Avi | HEK293 | 立即詢價 |
| CDA-HM432B | Biotinylated Fc gamma RIIA / CD32a (H167) | Human | C-His-Avi | HEK293 | 立即詢價 |
| FCR-HM42A | Fc gamma RIIA / CD32a (R167) | Human | C-His-Avi | HEK293 | 立即詢價 |
| FCR-HM42AB | Biotinylated Fc gamma RIIA / CD32a （R167） | Human | C-His-Avi | HEK293 | 立即詢價 |
| CDA-CM132 | Fc gamma RIIA / CD32a | Cynomolgus | C-His | HEK293 | 立即詢價 |
| CDB-HM401 | Fc gamma RIIB/C (CD32b/c) | Human | C-His-Avi | HEK293 | 立即詢價 |
| CDB-HM401-UL | Fc gamma RIIB/C (CD32b/c), Ultra Low Endotoxin | Human | C-His-Avi | HEK293 | 立即詢價 |
| CDB-HM401B | Biotinylated Fc gamma RIIB/C (CD32b/c) | Human | C-His-Avi | HEK293 | 立即詢價 |
| CDB-CM101 | Fc gamma RIIB | Cynomolgus | C-His | HEK293 | 立即詢價 |
| CDB-MM101 | Fc gamma RIIB / CD32b | Mouse | C-His | HEK293 | 立即詢價 |
| FGR-CM1R3 | Fc gamma RIII / CD16 | Cynomolgus | C-His | HEK293 | 立即詢價 |
| FGR-CM1R3-UL | Fc gamma RIII / CD16, Ultra Low Endotoxin | Cynomolgus | C-His | HEK293 | 立即詢價 |
| FGR-CM4R3B | Biotinylated Fc gamma RIII / CD16 | Cynomolgus | C-His-Avi | HEK293 | 立即詢價 |
| FGR-MM1R3 | Fc gamma RIII / CD16 | Mouse | C-His | HEK293 | 立即詢價 |
| FGR-MM4R3B | Fc gamma RIII / CD16 | Mouse | C-His-Avi | HEK293 | 立即詢價 |
| FCR-HM13A | Fc gamma RIIIA / CD16a (V176) | Human | C-His | HEK293 | 立即詢價 |
| FCR-HM43AB | Biotinylated Fc gamma RIIIA / CD16a (V176) | Human | C-His-Avi | HEK293 | 立即詢價 |
| FCR-HM31D | Fc gamma RIIIA / CD16a (V176) | Human | C-mFc | HEK293 | 立即詢價 |
| CDA-HM416 | Fc gamma RIIIA / CD16a (F176) | Human | C-His-Avi | HEK293 | 立即詢價 |
| CDA-HM416B | Biotinylated Fc gamma RIIIA / CD16a (F176) | Human | C-His-Avi | HEK293 | 立即詢價 |
| FCR-HM11B | Fc gamma RIIIB / CD16b (NA1) | Human | C-His | HEK293 | 立即詢價 |
| FCR-HM41BB | Biotinylated Fc gamma RIIIB / CD16b (NA1) | Human | C-His-Avi | HEK293 | 立即詢價 |
| FCR-HM42B | Fc gamma RIIIB /CD16b(NA2) | Human | C-His-Avi | HEK293 | 立即詢價 |
| FCR-HM42BB | Biotinylated Fc gamma RIIIB / CD16b | Human | C-His-Avi | HEK293 | 立即詢價 |
| FCR-MM162 | Fc gamma RIV / CD16-2 | Mouse | C-His | HEK293 | 立即詢價 |
| FRN-HM101 | FcRn | Human | C-His | HEK293 | 立即詢價 |
| FRN-HM401B | FcRn | Human | C-His-Avi | HEK293 | 立即詢價 |
| FRN-MM101 | FcRn | Mouse | C-His | HEK293 | 立即詢價 |
| FRN-MM401B | FcRn | Mouse | C-His-Avi | HEK293 | 立即詢價 |
| FRN-CM101 | FcRn | Cynomolgus | C-His | HEK293 | 立即詢價 |
| FRN-CM401B | FcRn | Cynomolgus | C-His-Avi | HEK293 | 立即詢價 |
| FRN-RM101 | FcRn | Rat | C-His | HEK293 | 立即詢價 |
| FRN-RM401B | FcRn | Rat | C-His-Avi | HEK293 | 立即詢價 |
| FER-HM101 | Fc epsilon RI alpha / FCER1a | Human | C-His | HEK293 | 立即詢價 |
| FER-HM201 | Fc epsilon RI alpha / FCER1a | Human | C-hFc | HEK293 | 立即詢價 |
| FER-HM201-UL | Fc epsilon RI alpha / FCER1a, Ultra Low Endotoxin | Human | C-hFc | HEK293 | 立即詢價 |
| FER-MM201 | Fc epsilon RI alpha / FCER1a | Mouse | C-hFc | HEK293 | 立即詢價 |
| CD3-HM123 | Fc epsilon RII / CD23 | Human | N-His | HEK293 | 立即詢價 |
| CD3-HM123B | Biotinylated Fc epsilon RII / CD23 | Human | N-His-Avi | HEK293 | 立即詢價 |
| IGG-HM001 | IgG1 Fc | Human | No Tag | HEK293 | 立即詢價 |
| IGG-HM001-UL | IgG1 Fc, Ultra Low Endotoxin | Human | No Tag | HEK293 | 立即詢價 |
| MFC-MM001 | IgG1 Fc | Mouse | No Tag | HEK293 | 立即詢價 |
| IGG-HM004 | IgG4 Fc | Human | No Tag | HEK293 | 立即詢價 |
| IGG-HM004-UL | IgG4 Fc, Ultra Low Endotoxin | Human | No Tag | HEK293 | 立即詢價 |
