FGFR系列蛋白
FGFR（Fibroblast Growth Factor Receptors），即成纖維細胞生長因子受體，一般包括FGFR1-4（也稱CD331-334）四種類型。FGFR是酪氨酸酶受體家族的一支，為I型跨膜蛋白，包括胞外區(qū)、跨膜區(qū)和胞質(zhì)區(qū)，通常以二聚體形式發(fā)揮作用。其中，胞外結(jié)構(gòu)域包含三個Ig樣區(qū)域D1（IgI）、D2（IgII）、D3（IgIII），其中D1和Acidic box組成自抑制區(qū)；D2和D3負責與配體結(jié)合（D2與細胞表面硫酸乙酰肝素結(jié)合，D3由于可變剪接有IIIb和IIIc兩種形式，F(xiàn)GFR4中目前只發(fā)現(xiàn)IIIc一種亞型）。根據(jù)Ig樣結(jié)構(gòu)域的個數(shù)，F(xiàn)GFR可分為兩種形式，一種是α型，含有IgI, IgII, IgIII三個區(qū)域；另一種是β型，只含IgII和IgIII。
FGFR結(jié)構(gòu)（Babina IS, et al., 2017）
FGFR的配體為FGF，目前已發(fā)現(xiàn)的人FGF有18種，除了FGF19、FGF21、FGF23是內(nèi)分泌外，其余皆為旁分泌產(chǎn)生，其中FGF7只能與IIIb型的FGFR2結(jié)合。FGFR與FGF結(jié)合介導(dǎo)了RAS-RAF-MAPK、PI3K-AKT、JAK-STAT以及PLCγ等信號通路的激活傳遞，參與細胞生長、分化、遷移、新血管生成、調(diào)節(jié)器官發(fā)育和傷口愈合等重要生理過程。FGFR基因變異通常在肺癌、肝癌、肝內(nèi)膽管癌、乳腺癌、胃癌、子宮癌及膀胱癌等實體瘤中廣泛存在，并且不同癌種的FGFR突變類型及頻率也存在差異。
FGF-FGFR介導(dǎo)的信號通路（Mason I, 2007）
愷佧生物深入分析了FGFR家族蛋白的結(jié)構(gòu)差異，成功制備出多種類型FGFR重組蛋白，涵蓋了α和β亞型，以及IIIb和IIIc等不同形式，助力FGFR靶向藥物的差異化研究！
質(zhì)控示例
Human FGFR2 beta (IIIb) Protein（FGR-HM1BB）
Immobilized Human FGFR2 beta(IIIb) at 0.5μg/ml on the plate. Dose response curve for Anti-FGFR2 Ab., hFc Tag with the EC50 of 20.2ng/ml determined by ELISA.
Anti-FGFR2 Ab., hFc Tag can bind Human FGFR2 beta IIIb, His Tag with an affinity constant of 1.98nM as determined in a SPR assay (Biacore T200).
Human FGFR2 alpha (IIIb) Protein（FGR-HM1BD）
Serial dilutions of Anti-FGFR2 alpha (IIIb) Antibody were added into Human FGFR2 alpha (IIIb), His Tag : Biotinylated Human FGF10, No Tag binding reactioins.
產(chǎn)品列表
| 貨號 | 蛋白名稱 | 種屬 | 標簽 | 表達體系 | |
|---|---|---|---|---|---|
| FGF-HM4RA | Human FGFR1 alpha (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGF-HM4RAB | Biotinylated Human FGFR1 alpha (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGF-HM2RA | Human FGFR2 alpha (IIIb) Protein | Human | C-hFc | HEK293 | 立即詢價 |
| FGR-HM1BD | Human FGFR2 alpha (IIIb) Protein | Human | C-His | HEK293 | 立即詢價 |
| FGF-HM4ABB | Biotinylated Human FGFR2 alpha (IIIb) Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGR-HM2CD | Human FGFR2 alpha (IIIc) Protein | Human | C-His | HEK293 | 立即詢價 |
| FGR-HM4CDB | Biotinylated Human FGFR2 alpha (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGR-HM1BB | Human FGFR2 beta (IIIb) Protein | Human | C-His | HEK293 | 立即詢價 |
| FGR-HM4BBB | Biotinylated Human FGFR2 beta (IIIb) Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGF-HM12D | Human FGFR2 beta (IIIb) Protein | Human | C-His | HEK293 | 立即詢價 |
| FGF-CM1BB | Cynomolgus FGFR2 beta (IIIb) Protein | Cynomolgus | C-His | HEK293 | 立即詢價 |
| FGF-MM1BB | Mouse FGFR2 beta (IIIb) Protein | Mouse | C-His | HEK293 | 立即詢價 |
| FGR-HM1BC | Human FGFR2 beta (IIIc) Protein | Human | C-His | HEK293 | 立即詢價 |
| FGR-HM4BCB | Biotinylated Human FGFR2 beta (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGF-HM43B | Human FGFR3 alpha (IIIb) Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGF-HM43BB | Biotinylated Human FGFR3 alpha (IIIb) Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGF-HM43C | Human FGFR3 alpha (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGF-HM43CB | Biotinylated Human FGFR3 alpha (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGF-HM4BB | Human FGFR3 beta (IIIb) Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGF-HM4BBB | Biotinylated Human FGFR3 beta (IIIb) Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGF-HM4BC | Human FGFR3 beta (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGF-HM4BCB | Biotinylated Human FGFR3 beta (IIIc) Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGF-HM4R4 | Human FGFR4 Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGF-HM2BD | Human FGFR2 beta (IIIb) Domain Protein | Human | C-hFc | HEK293 | 立即詢價 |
| FGR-HM2BB | Human FGFR2 beta (IIIb) Protein | Human | C-hFc | HEK293 | 立即詢價 |
| FGF-HM2R4 | Human FGFR4 Protein | Human | C-hFc | HEK293 | 立即詢價 |
| FGF-HM4R4B | Biotinylated Human FGFR4 Protein | Human | C-His-Avi | HEK293 | 立即詢價 |
| FGF-HE001 | Human FGF basic | Human | No Tag | E.coli | 立即詢價 |
| KGF-HE101 | Human FGF-7/KGF | Human | N-His | E.coli | 立即詢價 |
| FGF-HE010 | Human FGF10 | Human | No Tag | E.coli | 立即詢價 |
| FGF-HM621 | Human FGF21 | Human | N-mFc-Avi | HEK293 | 立即詢價 |
| FGF-HM121 | Human FGF21 | Human | N-His | HEK293 | 立即詢價 |
| FGF-HM621B | Biotinylated Human FGF21 | Human | N-mFc-Avi | HEK293 | 立即詢價 |
| FGF-MM121 | Mouse FGF21 | Mouse | N-His | HEK293 | 立即詢價 |
| KLB-HM101 | Human Beta-Klotho Protein | Human | C-His | HEK293 | 立即詢價 |
